Related Experiment Video
Updated: Feb 8, 2026

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
Endometrial CRH and implantation: from bench to bedside
Antonis Makrigiannakis1, Thomas Vrekoussis2, Emmanouel Zoumakis3
1Department of Obstetrics and Gynecology, School of Medicine, University of Crete, Heraklion, Crete, Greece. amakrigiannakis@gmail.com.
Abstract:
Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer.
Related Concept Videos
Hypothalamic-Pituitary Axis
Cleavage and Blastulation
Reproductive Cloning
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Bacterial Signaling
In-vitro Mutagenesis

