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A model for transposon-based eucaryote regulatory evolution.

C C King

    Journal of Theoretical Biology
    |June 7, 1985
    PubMed
    Summary
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    Transposable elements and RNA-based gene regulation formed a symbiotic relationship, driving eukaryote evolution. This structural symbiosis facilitated integral evolution through genetic exchange and germline mapping of mutations.

    Area of Science:

    • Evolutionary biology
    • Molecular biology
    • Genetics

    Background:

    • Transposable elements (TEs) are mobile genetic sequences with significant evolutionary impact.
    • Eukaryotic genome complexity suggests sophisticated regulatory mechanisms.
    • RNA-based gene regulation plays a crucial role in cellular processes.

    Purpose of the Study:

    • To present a compact model for the role of transposable elements in eukaryote evolution.
    • To propose a symbiotic relationship between TEs and RNA-based gene regulation as a driver of eukaryotic emergence.
    • To explain how this symbiosis leads to integral evolution.

    Main Methods:

    • Theoretical modeling based on existing experimental data and gene regulation theories.
    • Postulating a 'structural symbiosis' between TEs and RNA-based gene regulation.

    Related Experiment Videos

  • Analyzing the concept of selective mutagenesis and integral evolution (exogenous and endogenous).

    • Main Results:

    • A model where TEs and RNA-based gene regulation co-evolved, termed 'structural symbiosis'.
    • Selective mutagenesis allows beneficial regulatory mutations from TEs with reduced risk to structural genes.
    • Integral evolution encompasses exogenous (interspecies) and endogenous (germline) genetic information transfer.

    Conclusions:

    • The proposed structural symbiosis is a key factor in the emergence of eukaryotes.
    • This model integrates TE activity with gene regulation for a novel perspective on evolution.
    • The model provides a framework for understanding both horizontal and vertical gene transfer in evolution.