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Obesity Does Not Affect Early Outcomes in Children With Newly Diagnosed Crohn Disease

Animesh Jain1, Josh Bricker2, Michael D Kappelman3

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

Journal of Pediatric Gastroenterology and Nutrition
|June 20, 2018
PubMed

Insights

Obesity does not negatively impact pediatric Crohn disease (CD) outcomes in the first year after diagnosis. Overweight and obese children with newly diagnosed CD showed similar remission rates and health status compared to normal-weight peers.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Obesity and Child Health

Background:

  • The influence of obesity on pediatric Crohn disease (CD) is not well understood.
  • Characterizing outcomes in overweight and obese children with CD is crucial for effective management.

Purpose of the Study:

  • To assess disease-related outcomes in overweight and obese children diagnosed with CD.
  • To compare outcomes between normal-weight, overweight, and obese pediatric CD patients.

Main Methods:

  • Retrospective cohort study utilizing data from the ImproveCareNow Network.
  • Stratification of newly diagnosed pediatric CD patients into normal weight, overweight, and obese groups based on weight percentiles.
  • Analysis of outcomes including remission rates, nutritional status, growth, and medication use at 1-year follow-up.

Main Results:

  • No significant differences were observed in remission rates at 1 year between weight groups.
  • Nutritional status, growth parameters, and medication requirements were similar across normal weight, overweight, and obese children.
  • Baseline characteristics were comparable among the different weight strata.

Conclusions:

  • Obesity does not appear to adversely affect key disease outcomes in children with newly diagnosed CD within the first year post-diagnosis.
  • Findings suggest that current management strategies may be effective regardless of weight status in the initial phase of pediatric CD.
  • Further research may explore long-term impacts and specific interventions for obese pediatric CD patients.

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