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Updated: Feb 8, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Primary stroke prevention: a paradigm shift focusing on silent paroxysmal atrial fibrillation
1From the Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel.
Insights
Silent sub-clinical atrial fibrillation (SCAF) is common in older adults and raises stroke risk. Active screening and early treatment with anticoagulants for high-risk elderly patients can reduce mortality and morbidity.
Area of Science:
- Cardiology
- Neurology
- Geriatrics
Background:
- Silent sub-clinical atrial fibrillation (SCAF) is highly prevalent in the elderly.
- SCAF significantly increases the risk of stroke and cardiovascular mortality.
- Current detection methods for atrial fibrillation are often reactive and limited.
Purpose of the Study:
- To advocate for a proactive approach to identify high-risk elderly individuals with SCAF.
- To emphasize the importance of early detection and intervention for SCAF.
- To reduce SCAF-associated morbidity and mortality in the aging population.
Main Methods:
- Review of prevalence, predictability, prognosis, and preventability of atrial fibrillation and cardiogenic brain embolism.
- Focus on identifying SCAF in individuals over 65.
- Utilizing readily available clinical, electrocardiographic, echocardiographic, and laboratory markers for risk assessment.
Main Results:
- SCAF is a common and significant risk factor for stroke in the elderly.
- Routine evaluation of specific markers can identify high-risk patients.
- Early detection facilitates timely treatment with direct oral anticoagulants.
Conclusions:
- A proactive screening strategy for SCAF in the elderly is warranted.
- Early identification and treatment of SCAF can significantly decrease stroke risk and mortality.
- Integrating SCAF detection into general practice and specialist consultations is feasible and beneficial.
Abstract:
We review the prevalence, predictability, prognosis and preventability of atrial fibrillation and associated cardiogenic brain embolism, focusing on 'silent' sub-clinical atrial fibrillation (SCAF) which is very common in the elderly and associated with significantly increased risk of stroke and cardiovascular mortality. The current paradigm treats atrial fibrillation once discovered by its symptoms, complications (stroke) or by chance and screening recommendations are limited to opportunistic pulse palpation. We argue that the marked incidence of SCAF in patients over 65 justifies a much more active approach to identify patients at a particularly high-risk by routine evaluation of readily-available clinical, electrocardiographic, echocardiographic and laboratory markers. Elderly patients at high-risk need further monitoring by suitable devices (occasionally, long-term) and treatment with direct oral anti-coagulants once SCAF is revealed. This approach can already be adopted during clinical encounters at the general practitioner and consultant level, to decrease the substantial SCAF-associated morbidity and mortality.
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