Primary stroke prevention: a paradigm shift focusing on silent paroxysmal atrial fibrillation

A Schattner1

  • 1From the Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel.

Insights

Silent sub-clinical atrial fibrillation (SCAF) is common in older adults and raises stroke risk. Active screening and early treatment with anticoagulants for high-risk elderly patients can reduce mortality and morbidity.

Area of Science:

  • Cardiology
  • Neurology
  • Geriatrics

Background:

  • Silent sub-clinical atrial fibrillation (SCAF) is highly prevalent in the elderly.
  • SCAF significantly increases the risk of stroke and cardiovascular mortality.
  • Current detection methods for atrial fibrillation are often reactive and limited.

Purpose of the Study:

  • To advocate for a proactive approach to identify high-risk elderly individuals with SCAF.
  • To emphasize the importance of early detection and intervention for SCAF.
  • To reduce SCAF-associated morbidity and mortality in the aging population.

Main Methods:

  • Review of prevalence, predictability, prognosis, and preventability of atrial fibrillation and cardiogenic brain embolism.
  • Focus on identifying SCAF in individuals over 65.
  • Utilizing readily available clinical, electrocardiographic, echocardiographic, and laboratory markers for risk assessment.

Main Results:

  • SCAF is a common and significant risk factor for stroke in the elderly.
  • Routine evaluation of specific markers can identify high-risk patients.
  • Early detection facilitates timely treatment with direct oral anticoagulants.

Conclusions:

  • A proactive screening strategy for SCAF in the elderly is warranted.
  • Early identification and treatment of SCAF can significantly decrease stroke risk and mortality.
  • Integrating SCAF detection into general practice and specialist consultations is feasible and beneficial.

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.2K