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Updated: Feb 8, 2026

Transdermal Measurement of Glomerular Filtration Rate in Mice
Published on: October 21, 2018
Glomerular Filtration Rate in Patients with Multiple Sclerosis Undergoing Stem Cell Transplantation and Treated with
Alejandro Ruiz-Argüelles1,2, Jose M Gastélum-Cano1,2, Mariana A Méndez-Huerta1,2
1Department of Immunology, Laboratorios Clínicos de Puebla. Puebla, México.
Background:
Glomerular filtration rate (GFR) is partially impaired in patients with multiple sclerosis (MS). When given chemotherapy before receiving hematopoietic stem-cell transplantation, GFR might be further deteriorated.
Objective:
To measure the effect of cyclophosphamide on GFR in patients with MS who undergo chemotherapy.
Methods:
We estimated GFR based on creatinine and cystatin C plasma concentrations in patients undergoing autologous hematopoietic stem-cell transplantation to treat their MS.
Results:
Baseline GFR values were lower in the 28 patients with MS than in the 20 healthy individuals. Also, according to the Chronic Kidney Disease-Epidemiology Collaborative Group (CKD-EPI) 2012 Creat-CysC equation criteria, 4 of 28 patients were classified as having chronic kidney disease (CKD) before receiving the chemotherapy drugs. After receiving 4 × 50 mg per kg body weight cyclophosphamide, abnormal GFR results were recorded in 12 of 28 patients.
Conclusions:
Renal function must be monitored in patients with MS undergoing autologous stem-cell transplantation. Also, chemotherapy should be constrained as much as possible to prevent further deterioration of renal function.
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