Related Experiment Video
Updated: Feb 8, 2026
03:22
Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
Published on: March 1, 2024
909
CRISPR technology: new paradigm to target the infectious disease pathogens
M A Bakhrebah1, M S Nassar, M S Alsuabeyl
1Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia. sultanmeo@hotmail.com.
European Review for Medical and Pharmacological Sciences
|June 20, 2018
Summary
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology offers a novel approach to combat infectious diseases by targeting and neutralizing pathogens. This innovative genome editing tool shows promise in developing new therapies for various microbial infections.
Area of Science:
- Molecular Biology
- Genetics
- Microbiology
Background:
- Infectious diseases represent a significant global health burden, contributing to mortality worldwide.
- Sequence-specific gene editing technologies are emerging as powerful tools against pathogens.
Purpose of the Study:
- To review the mechanisms and therapeutic applications of CRISPR/Cas9 genome editing for infectious disease management.
- To explore the potential of CRISPR technology in treating a wide range of infectious agents.
Main Methods:
- A comprehensive literature search was performed using PubMed.
- Keywords included "CRISPR", "Cas-9", "Genome editing", "Gene therapy", and "infectious disease pathogens".
Main Results:
- CRISPR technology enables precise modification and regulation of gene expression.
- It aids in understanding fundamental biological processes and developing treatments for infectious conditions.
Conclusions:
- CRISPR applications are extensive in diagnosing and treating bacterial, viral, fungal, and parasitic infections.
- This technology is effective for correcting genetic defects and eliminating foreign DNA in infectious diseases.
Related Concept Videos
01:59CRISPR
58.0K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
58.0K
02:53CRISPR and crRNAs
19.2K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
19.2K
01:31Hybridoma Technology
17.7K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.7K
02:26Defenses Against Pathogens and Herbivores
29.6K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.6K
01:31Defense Against Bacterial Pathogens
2.9K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.9K
01:30Health Information Technology and Healthcare Information System
3.4K
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
3.4K