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Effect of nano-sized SiO2 particles on the cognitive function and biochemical response
Amara Salem1,2, Amal Oudhabechi1, Mohsen Sakly1
1a Laboratory of Integrated Physiology, Faculty of Science of Bizerte , Carthage University , Zarzouna, Tunisia.
Archives of Environmental & Occupational Health
|June 20, 2018
Summary
Sub-acute exposure to silicon dioxide nanoparticles (SiO2-NPs) impaired spatial learning and memory in rats. SiO2-NPs also caused changes in blood counts and induced liver damage, highlighting in vivo toxicity concerns.
Area of Science:
- Nanotoxicology
- Neuroscience
- Biochemistry
Background:
- In vitro studies indicate silicon dioxide nanoparticles (SiO2-NPs) cause dose-, time-, and size-dependent cytotoxicity.
- Existing in vivo toxicity data for SiO2-NPs are contradictory, necessitating further investigation.
Purpose of the Study:
- To investigate the in vivo effects of sub-acute exposure to SiO2-NPs on spatial learning and memory in rats.
- To assess the impact of SiO2-NPs on biochemical parameters and organ histology.
Main Methods:
- Rats received intravenous injections of SiO2-NPs (20 mg/kg) daily for five consecutive days.
- Spatial learning and memory were evaluated using the Morris water maze.
- Blood counts, biochemical markers, and organ histology were analyzed.
Main Results:
- SiO2-NPs significantly disrupted spatial learning and memory in rats.
- Alterations in blood counts were observed following SiO2-NP exposure.
- Histological examination revealed pathological changes in organs, including granuloma formation and inflammatory cell infiltration in the liver.
- Biochemical markers remained largely unchanged.
Conclusions:
- Sub-acute exposure to SiO2-NPs negatively impacts cognitive function and induces organ pathology in rats.
- The findings underscore the potential in vivo risks associated with SiO2-NPs, particularly concerning neurological and hepatic effects.
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