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Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach
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Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene.

Breeanne M Soteros1, Qifei Cong1, Christian R Palmer2

  • 1Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.

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|June 20, 2018
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Summary

The sushi domain protein SRPX2 is crucial for brain development, impacting neural circuits and communication. Mice lacking SRPX2 show reduced excitatory synapses and altered social behaviors, highlighting its role in vocalization and social development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The transcription factor FoxP2 is linked to developmental brain disorders affecting language.
  • The precise mechanisms by which FoxP2 influences neural circuitry development are not fully understood.
  • Mutations in SRPX2, a FoxP2 target gene, are associated with human language deficits.

Purpose of the Study:

  • To characterize the function of the sushi domain protein SRPX2 in neural development.
  • To investigate the role of SRPX2 in regulating neural circuitry, communication, and social behaviors.
  • To elucidate the contribution of SRPX2 to FoxP2-mediated regulation of vocalization and social circuits.

Main Methods:

  • Generation and analysis of mice lacking the SRPX2 gene (SRPX2 knockout).
  • Assessment of excitatory and inhibitory synapse density in the cerebral cortex using VGlut1 and VGlut2 markers.
  • Evaluation of ultrasonic vocalization patterns in neonatal pups and social novelty preference in adult mice.

Main Results:

  • SRPX2 knockout mice exhibit a specific reduction in excitatory VGlut2 synapses in the cerebral cortex.
  • VGlut1 and inhibitory synapses remained largely unaffected in SRPX2 knockout mice.
  • SRPX2 knockout mice displayed abnormal ultrasonic vocalization ontogeny and reduced preference for social novelty.

Conclusions:

  • SRPX2 plays a critical functional role during brain development.
  • The study implicates FoxP2 and its target SRPX2 in the development of vocalization and social circuits.
  • Defects in SRPX2 are linked to alterations in neural circuitry, communication, and social behaviors.