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The Mesentery, Systemic Inflammation, and Crohn's Disease
Edgardo D Rivera1, John Calvin Coffey2,3, Dara Walsh3
1Division of Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Mailman Center for Child Development, Miami, Florida.
Inflammatory Bowel Diseases
|June 20, 2018
Summary
The mesentery, once considered just supportive tissue, is now recognized as a key organ in inflammatory diseases like Crohn's disease. Understanding its role is crucial for developing better treatments and surgical approaches.
Area of Science:
- Gastroenterology and Immunology
- Surgical Pathology
Background:
- The mesentery was historically viewed solely as supportive tissue for abdominal organs.
- Emerging research highlights the mesentery's role as an independent organ implicated in local and systemic inflammation.
- Its association with Crohn's disease, particularly
- creeping fat
- warrants further investigation.
Purpose of the Study:
- To review the anatomical and embryological significance of the mesentery.
- To summarize current data on mesenteric inflammation in Crohn's disease patients.
- To explore the mesentery's role in systemic inflammatory syndromes and primary mesenteric disorders.
Main Methods:
- Literature review encompassing anatomical, embryological, and clinical data.
- Analysis of studies on mesenteric inflammation and its link to Crohn's disease.
- Examination of surgical strategies involving mesenteric factors for Crohn's disease.
Main Results:
- The mesentery plays a significant role in the pathogenesis of Crohn's disease, evidenced by inflammation and "creeping fat".
- Mesenteric inflammation is linked to systemic inflammatory conditions.
- Surgical approaches that consider mesenteric factors show promise in improving outcomes for Crohn's disease.
Conclusions:
- The mesentery is a critical factor in Crohn's disease pathogenesis and systemic inflammation.
- Further research into mesenteric inflammation and its management is essential.
- Incorporating mesenteric considerations into surgical resections may enhance patient outcomes and reduce recurrence in Crohn's disease.