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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Introduction to Hemostasis01:05

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Basophil Activation Test for Allergy Diagnosis
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Hemostasis in Allergy.

Zahava Vadasz1, Elias Toubi1

  • 1Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel.

Seminars in Thrombosis and Hemostasis
|June 20, 2018
PubMed
Summary

The hemostatic system, involving coagulation factors, plays a key role in immune-mediated inflammation, asthma, and chronic spontaneous urticaria (CSU). Targeting these factors offers a new therapeutic approach for these conditions.

Area of Science:

  • * Immunology
  • * Hematology
  • * Respiratory Medicine

Background:

  • * The hemostatic system is increasingly recognized for its role in immune-mediated inflammatory conditions.
  • * Coagulation factors are implicated in the pathogenesis of autoimmune diseases like systemic vasculitis and lupus erythematosus.
  • * Hemostatic disorders are also linked to respiratory conditions such as asthma and chronic spontaneous urticaria (CSU).

Purpose of the Study:

  • * To review the literature on the involvement of hemostasis in immune-mediated inflammation, asthma, and CSU.
  • * To highlight the role of specific coagulation factors, particularly Factor XIIa (FXIIa), in these conditions.
  • * To discuss FXIIa as a potential therapeutic target for immune-mediated inflammatory diseases.

Main Methods:

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  • * Narrative review of existing scientific literature.
  • * Synthesis of data linking hemostatic factors to inflammatory pathways.
  • * Focus on studies investigating coagulation factors in asthma and CSU pathogenesis.

    • Main Results:

    • * Coagulation factors like tissue factor and fibrinogen are involved in asthma pathogenesis.
    • * Platelet activation is observed in asthma, suggesting a link between bronchial inflammation and hemostasis.
    • * Factor XIIa (FXIIa) activation, fibrinogen, and elevated D-dimer levels are associated with CSU and mast cell degranulation.

    Conclusions:

    • * The hemostatic system is significantly involved in immune-mediated inflammation, asthma, and CSU.
    • * Factor XIIa (FXIIa) is a key player and a promising therapeutic target in these inflammatory conditions.
    • * Understanding the interplay between hemostasis and immunity can lead to novel treatment strategies.