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Botanicals and Hepatotoxicity.

Marina M Roytman1, Peter Poerzgen2, Victor Navarro3

  • 1University of California San Francisco, Fresno, California, USA.

Clinical Pharmacology and Therapeutics
|June 20, 2018
PubMed
Summary
This summary is machine-generated.

Herbal dietary supplements (HDS) are increasingly popular but pose risks, including liver damage. This review examines HDS-associated hepatotoxicity, consumer trends, and regulatory challenges to improve consumer safety.

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Area of Science:

  • Pharmacology
  • Hepatology
  • Public Health

Background:

  • The widespread use of multi-ingredient herbal dietary supplements (HDS) has surged over the past 30 years.
  • This rise is concurrent with an increase in health issues linked to dietary supplements (DS), particularly liver toxicity (hepatotoxicity).
  • The efficacy of many HDS remains unproven, raising concerns about consumer safety.

Purpose of the Study:

  • To review the demographics and motivations of individuals using dietary supplements (DS).
  • To examine the regulatory landscape governing DS in the US and other developed nations.
  • To detail specific multi-ingredient HDS linked to hepatotoxicity and discuss challenges in establishing causality.

Main Methods:

  • Review of scientific literature on HDS, consumer behavior, and regulatory policies.
  • Detailed case analysis of three HDS categories associated with liver injury: OxyElite Pro, green tea extract-based supplements, and "designer anabolic steroids."
  • Examination of clinical and regulatory challenges in identifying causative agents in multi-ingredient HDS.

Main Results:

  • Identified key demographic factors and consumer motivations driving HDS use.
  • Highlighted regulatory gaps and complexities in overseeing the DS market.
  • Illustrated the difficulty in pinpointing specific ingredients responsible for HDS-induced liver injury using clinical examples.

Conclusions:

  • Multi-ingredient HDS pose significant risks, including hepatotoxicity, necessitating further research.
  • Current regulatory frameworks face challenges in effectively safeguarding consumers from harmful DS.
  • Recommendations for future research and consumer protection measures are proposed to mitigate HDS-associated liver injury.