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Updated: Feb 8, 2026
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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[Correlation between prognosis and IL-33 expression in head and neck squamous cell carcinoma]
1Department of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University,Guangzhou Key Laboratory of Otorhinolaryngology,Guangzhou, 510080,China.
Summary
Interleukin-33 (IL-33) expression is lower in head and neck squamous cell carcinoma (HNSCC) tissues and correlates with poorer patient prognosis. Low IL-33 levels indicate advanced disease and predict a worse outcome in HNSCC patients.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Head and neck squamous cell carcinoma (HNSCC) is a significant global health concern.
- The role of Interleukin-33 (IL-33) in HNSCC pathogenesis and prognosis requires further elucidation.
Purpose of the Study:
- To investigate the correlation between IL-33 expression and clinicopathological features in HNSCC.
- To assess IL-33 as a potential prognostic biomarker for HNSCC patients.
Main Methods:
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were employed.
- IL-33 mRNA and protein expression were analyzed in 107 HNSCC tumor tissues and adjacent normal tissues.
- Correlation analysis was performed between IL-33 levels and patient clinicopathological characteristics.
Main Results:
- IL-33 mRNA and protein expression were significantly lower in HNSCC tissues compared to normal tissues.
- Reduced IL-33 levels correlated with advanced T stages, lymph node metastasis, and advanced clinical stages.
- Higher IL-33 expression was observed in well-differentiated tumors, and low IL-33 expression predicted poor prognosis.
Conclusions:
- IL-33 expression is closely associated with clinicopathological features in HNSCC.
- IL-33 serves as an independent predictive factor for HNSCC patient prognosis.
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