Related Experiment Video

Updated: Feb 8, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

27.8K

The effect of combined therapy for treatment of monotherapy-resistant PDA in preterm infants

Sadık Yurttutan1, Aydın Bozkaya1, Füheda Hüdayioglu2

  • 1a Department of Pediatrics, Faculty of Medicine , Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 21, 2018
PubMed

Insights

Combined therapy with paracetamol and ibuprofen effectively treated hemodynamically significant PDA (hsPDA) in preterm infants resistant to single-drug treatment. This approach offers a viable alternative before considering surgical PDA ligation.

Area of Science:

  • Neonatalogy
  • Pediatric Cardiology

Background:

  • Hemodynamically significant PDA (hsPDA) is a common complication in preterm infants.
  • Monotherapy for hsPDA can be ineffective in some cases, necessitating alternative treatments.

Purpose of the Study:

  • To evaluate the efficacy of combined paracetamol and ibuprofen therapy for hsPDA in preterm infants.
  • To assess this combined treatment in infants with hsPDA resistant to monotherapy.

Main Methods:

  • Infants with persistent hsPDA unresponsive to monotherapy received combined paracetamol and ibuprofen.
  • Paracetamol was administered at 15 mg/kg every 6 hours for 5 days, with ibuprofen given at 10 mg/kg followed by 5 mg/kg at 24 and 48 hours.
  • Echocardiography assessed hsPDA after treatment; surgical ligation was considered for persistent cases.

Main Results:

  • Combined therapy successfully treated 75% (9 out of 12) of infants with monotherapy-resistant hsPDA.
  • Three infants did not respond to the combined treatment and subsequently underwent surgical PDA ligation.

Conclusions:

  • Combined paracetamol and ibuprofen therapy presents a promising option for treating monotherapy-resistant hsPDA in preterm infants.
  • This combined pharmacological approach should be considered prior to surgical intervention for hsPDA.

Keywords:
Paracetamolcombined therapyibuprofenpatent ductus arteriosuspreterms

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

13.5K
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

657

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
633
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K