Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis
YuJing Wu1, ZhiJuan Fan1, YaQiong Tian1
1Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, No. 83, Jintang Road, Hedong District, Tianjin, China.
Insights
Higher levels of high-density lipoprotein (HDL) particles, not just HDL cholesterol, are linked to fewer cardiovascular events. This suggests HDL particles are a protective factor and potential therapeutic target for cardiovascular disease.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Biomarker Discovery
Background:
- Previous trials targeting high-density lipoprotein (HDL) cholesterol failed to improve cardiovascular outcomes.
- HDL particles may serve as more accurate biomarkers than HDL cholesterol concentration.
- This meta-analysis investigates the association between blood HDL particle levels and cardiovascular events.
Purpose of the Study:
- To evaluate the relationship between blood HDL particle concentration and cardiovascular events.
- To determine if HDL particles are a better indicator of cardiovascular risk than HDL cholesterol.
- To explore HDL particles as potential therapeutic targets for cardiovascular disease.
Main Methods:
- A systematic literature search was conducted using PubMed and other databases.
- Study quality was assessed using the NewCastle-Ottawa Quality Assessment Scale (NOS).
- Pooled hazard ratios (HR) were calculated using random or fixed-effect models.
Main Results:
- Twelve studies were included, revealing an inverse relationship between HDL particle levels and cardiovascular events.
- A per standard deviation (SD) increment in HDL particles showed a pooled HR of 0.79 (0.72, 0.86).
- Top quartile versus bottom quartile analysis yielded a pooled HR of 0.65 (0.57, 0.75), with smaller and medium HDL particles showing stronger inverse associations.
Conclusions:
- Blood HDL particle levels are inversely associated with cardiovascular disease (CVD) events.
- HDL particles may act as a protective factor, particularly in patients with existing CVD.
- HDL particles represent a promising biomarker and potential therapeutic target for managing cardiovascular disease.
Background:
Trails aimed at raising high density lipoprotein(HDL) cholesterol concentration failed to make better cardiovascular outcomes. HDL particles may be better biomarkers reflecting properties of HDL. This meta-analysis was conducted to evaluate the relation between blood HDL particles level and cardiovascular events.
Methods:
PubMed and other databases were searched for eligible studies and NewCastle-Ottawa Quality Assessment Scale(NOS) was used to assess the quality of included studies. A random or fixed-effect model was applied to calculate the pooled hazard ratio(HR).
Results:
Twelve studies were finally included. The pooled HR(95%confidence interval) for per standard deviation(SD) increment and top quartile versus bottom quartile were 0.79(0.72,0.86) and 0.65(0.57,0.75), respectively. Subgroup analysis suggested that HR was significantly lower in subjects with a cardiovascular disease(CVD) history than that of people without established CVD. Subclass analysis indicated that HRs for per SD increment of small(0.85) and medium(0.84) HDL particles were significantly lower than that of large HDL particles(0.96).
Conclusions:
HDL particle level in blood was inversely related to CVD events, indicating that HDL particles maybe a protective factor in patients with CVD, thus making HDL particles a potential biomarker and therapy target.
Related Concept Videos
01:24Relative Motion Analysis - Velocity
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...
01:10Relative Motion Analysis - Acceleration
01:25Relative Motion Analysis using Rotating Axes
However, to express the relative position of point B relative to point A, an additional frame of reference, denoted as x'y', is necessary. This additional frame not only translates but also rotates relative to the fixed frame, making it...
03:37Subatomic Particles
01:29Relative Motion Analysis using Rotating Axes-Problem Solving
Here, in order to determine the magnitude of velocity and acceleration for point...
02:48Expressing Solution Concentration
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.