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Evaluation of safety and efficacy of different continuous blood Purification methods in treating infantile sepsis

W B Li1, L Y Yin1, X Q Zhang2

  • 1Department of Infectious Disease, Xuzhou Children’s Hospital, Xuzhou, Jiangsu, P.R. China.

Journal of Biological Regulators and Homeostatic Agents
|June 21, 2018
PubMed

Insights

High volume hemofiltration (HVHF) is a more effective treatment for infantile sepsis than continuous veno-venous hemofiltration (CVVH). HVHF offers faster recovery and better reduction in inflammatory markers.

Area of Science:

  • Pediatric Critical Care Medicine
  • Nephrology
  • Intensive Care Medicine

Background:

  • Sepsis is a life-threatening condition in infants, necessitating effective continuous blood purification (CBP) methods.
  • Continuous veno-venous hemofiltration (CVVH) and high volume hemofiltration (HVHF) are two CBP techniques used in treating infantile sepsis.

Discussion:

  • This study compared the safety and efficacy of CVVH and HVHF in 86 pediatric sepsis patients.
  • Key parameters evaluated included survival rates, hemodynamic stability, inflammatory markers, and disease severity scores.
  • Results indicated no significant difference in survival or hemodynamic parameters between the two groups.

Key Insights:

  • High volume hemofiltration (HVHF) demonstrated a significantly shorter blood filtration duration and lower APACHE II scores compared to CVVH.
  • HVHF led to a more significant reduction in inflammatory markers such as procalcitonin, hs-CRP, and TXB2 post-therapy.
  • HVHF is suggested to be a safer and more effective CBP method for infantile sepsis.

Outlook:

  • Further research could explore long-term outcomes and cost-effectiveness of HVHF in pediatric sepsis.
  • Optimizing HVHF protocols may enhance its benefits in managing severe pediatric infections.
  • Investigating the precise mechanisms behind HVHF's superior inflammatory response modulation is warranted.

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