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Related Experiment Video

Updated: Feb 8, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Author Correction: New activities for old antibiotics.

Jeffrey I Cohen1

  • 1Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. jcohen@niaid.nih.gov.

Nature Microbiology
|June 21, 2018
PubMed
Summary
This summary is machine-generated.

Mice congenic for Mx1, an interferon-stimulated gene (ISG) crucial for influenza protection, showed improved survival after neomycin pretreatment. However, approximately 50% of these mice still died, indicating incomplete protection.

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Area of Science:

  • Virology
  • Immunology
  • Microbiology

Context:

  • Influenza virus poses a significant threat to animal health.
  • Interferon-stimulated genes (ISGs) play a critical role in antiviral defense.
  • Mx1 is a key ISG involved in protection against influenza.

Purpose:

  • To investigate the role of Mx1 in influenza protection in mice.
  • To evaluate the effect of neomycin pretreatment on survival rates in Mx1-congenic mice challenged with influenza.

Summary:

  • Mice congenic for Mx1, an ISG vital for influenza protection, were pretreated intranasally with neomycin.
  • This pretreatment significantly improved survival rates in the animals.
  • Despite the improvement, approximately 50% of the treated mice succumbed to the infection.

Impact:

  • Highlights the importance of Mx1 in host defense against influenza.
  • Suggests that neomycin may modulate the host immune response, offering partial protection.
  • Indicates that further research is needed to fully understand the mechanisms and improve therapeutic strategies against influenza.