Related Experiment Video
Updated: Feb 8, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
Published on: November 28, 2025
Preserving ECMO Cannulae Patency.
Jacob McNinch1, Bruce Searles1, Edward Darling1
1State University of New York Upstate Medical University, Syracuse, New York.
Minimal anticoagulation during extracorporeal membrane oxygenation (ECMO) risks circuit thrombosis. This system preserves ECMO cannula patency during prolonged flow stasis when flushing is not possible.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Critical Care
Background:
- Extracorporeal membrane oxygenation (ECMO) requires careful anticoagulation management.
- Minimal anticoagulation strategies increase susceptibility to circuit thrombosis.
- ECMO cannula thrombosis is a significant risk, especially during flow interruptions.
Purpose of the Study:
- To outline an emergency system for preserving ECMO cannula patency.
- To address the risk of thrombosis during prolonged cannula blood flow stasis.
- To provide a rapidly implementable plan for cannula patency preservation.
Main Methods:
- Development of a system for cannula patency preservation.
- Focus on emergency scenarios where flushing cannulae is not an option (e.g., air in circuit).
- Description of a protocol for maintaining patency during prolonged stasis.
Main Results:
- The proposed system aims to prevent ECMO cannula thrombosis.
- It offers a solution for critical situations with prolonged flow stasis.
- The system ensures rapid implementation for emergency use.
Conclusions:
- A dedicated system is crucial for maintaining ECMO cannula patency.
- This approach mitigates thrombosis risk in specific emergency scenarios.
- Effective emergency planning is vital for ECMO patient safety.
Related Concept Videos
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
What is Conservation Biology?
Sustainable Development
Keystone Species
The Fossil Record

