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Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
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Poor prognosis and SATB1 overexpression in solid tumors: a meta-analysis
Shengjie Wang1, Junjie Zeng1, Rui Xiao2
1Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.
Cancer Management and Research
|June 21, 2018
Summary
High special AT-rich sequence-binding protein 1 (SATB1) expression in solid tumors is linked to poorer patient survival. This meta-analysis confirms SATB1 as a potential prognostic biomarker for cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Previous studies suggest special AT-rich sequence-binding protein 1 (SATB1) has prognostic value in solid tumors.
- Inconsistent results and small sample sizes limited prior research.
- A meta-analysis was conducted to clarify the association between SATB1 and patient outcomes.
Purpose of the Study:
- To investigate the prognostic significance of SATB1 overexpression in patients with solid tumors.
- To consolidate evidence from multiple studies to determine the relationship between SATB1 and overall survival (OS).
Main Methods:
- A meta-analysis was performed on 17 studies comprising 3144 patients.
- Literature search conducted on PubMed, EMBASE, and Web of Science up to April 2017.
- Pooled hazard ratios (HR) for OS were quantitatively analyzed using univariate and multivariate methods.
Main Results:
- High SATB1 expression significantly predicted poor prognosis in solid tumors.
- Multivariate analysis showed a combined HR for OS of 1.82 (95% CI: 1.59-2.08, P < 0.0001).
- Univariate analysis yielded a pooled HR for OS of 1.96 (95% CI: 1.65-2.34, P < 0.0001).
Conclusions:
- Elevated SATB1 levels correlate significantly with reduced survival in most solid tumors.
- SATB1 demonstrates potential as a prognostic biomarker.
- SATB1 may represent a novel therapeutic target based on its expression levels in solid tumors.
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