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Decreased Bilateral FDG-PET Uptake and Inter-Hemispheric Connectivity in Multi-Domain Amnestic Mild Cognitive

Xiao Luo1, Kaicheng Li1, Qingze Zeng1

  • 1Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Aging Neuroscience
|June 21, 2018
PubMed

Insights

Multi-domain amnestic mild cognitive impairment (MD-aMCI) shows greater inter-hemispheric connectivity damage than single-domain aMCI (SD-aMCI). This reduced brain connectivity may indicate disease progression and correlate with cognitive decline.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Cognitive Neurology

Background:

  • Amnestic mild cognitive impairment (aMCI) is heterogeneous, classified as single-domain (SD-aMCI) or multi-domain (MD-aMCI).
  • Inter-hemispheric connectivity is crucial for cognitive functions.
  • Differences in inter-hemispheric connectivity between SD-aMCI and MD-aMCI remain under-investigated.

Purpose of the Study:

  • To investigate distinct inter-hemispheric connectivity patterns in SD-aMCI and MD-aMCI.
  • To correlate neuroimaging findings with cognitive performance and pathological biomarkers.

Main Methods:

  • Utilized 18F PET-FDG, resting-state fMRI, and structural T1 imaging in 49 controls, 32 SD-aMCI, and 32 MD-aMCI patients.
  • Analyzed voxel-wise 18F PET-FDG metabolism, voxel-mirrored homotopic connectivity (VMHC), and corpus callosum (CC) volumes.
  • Correlated inter-hemispheric indices with behavioral scores and biomarkers.

Main Results:

  • MD-aMCI patients exhibited more severe inter-hemispheric connectivity damage than SD-aMCI patients.
  • MD-aMCI showed hypometabolism (bilateral middle temporal gyrus, inferior parietal lobe, left precuneus) and decreased VMHC in several regions.
  • MD-aMCI also had smaller mid-posterior corpus callosum volumes; hypometabolism and connectivity deficits correlated with executive function and amyloid deposition.

Conclusions:

  • MD-aMCI is characterized by more significant deficits in inter-hemispheric communication compared to SD-aMCI.
  • These long-range connectivity deficits may underlie the distinct cognitive profiles observed in MD-aMCI.
  • Inter-hemispheric connectivity patterns could serve as potential biomarkers for tracking aMCI progression.
Keywords:
cerebral metabolismcorpus callosummild cognitive impairmentresting-state functional MRIvoxel-mirrored homotopic connectivity

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