Related Experiment Video
Updated: Feb 8, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
10.2K
DeCoST: A New Approach in Drug Repurposing From Control System Theory
Thanh M Nguyen1, Syed A Muhammad2, Sara Ibrahim3
1Department of Computer and Information Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United States.
Frontiers in Pharmacology
|June 21, 2018
Summary
We introduce the DeCoST framework, applying control system theory to drug repurposing. This novel approach identifies potential new cancer treatments by modeling drug-gene-disease interactions, offering a systematic and cost-effective discovery method.
Area of Science:
- Pharmacology and Systems Biology
- Control Theory Applications in Medicine
Background:
- Drug repurposing accelerates new treatment discovery for complex diseases.
- Existing methods evolve but often lack systematic, model-based approaches.
- Control system paradigms are underutilized for modeling drug-gene-disease networks.
Purpose of the Study:
- To introduce the DeCoST (Drug Repurposing from Control System Theory) framework.
- To apply control system theory to drug repurposing for identifying novel therapeutic strategies.
- To construct disease-specific mathematical models integrating drug, gene, and disease data.
Main Methods:
- Developed the DeCoST framework, integrating biological and pharmaceutical knowledge.
- Quantified connective data sources among drugs, genes, and diseases.
- Utilized linear-quadratic regulator control techniques to assess therapeutic effects.
- Validated the framework's ability to classify drug approval status.
Main Results:
- Successfully applied DeCoST to Breast Cancer (ER+ and ER-) and Bladder Cancer.
- Identified 8 candidate drugs for ER+ Breast Cancer (e.g., Erbitux, Flutamide).
- Identified 2 candidate drugs for ER- Breast Cancer (e.g., Daunorubicin, Donepezil).
- Identified 10 candidate drugs for Bladder Cancer (e.g., Zafirlukast, Tenofovir).
Conclusions:
- DeCoST provides a novel, systematic, and model-based approach to drug repurposing.
- The framework demonstrates potential for identifying promising candidate drugs for various cancers.
- Control theory offers a powerful paradigm for understanding complex biological systems in drug discovery.
More Related Videos
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
475
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
475
02:45Self-Discrepancy Theory
18.9K
One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.
18.9K
02:45Valence Bond Theory
50.3K
Overview of Valence Bond Theory
50.3K
02:35Band Theory
17.3K
When two or more atoms come together to form a molecule, their atomic orbitals combine and molecular orbitals of distinct energies result. In a solid, there are a large number of atoms, and therefore a large number of atomic orbitals that may be combined into molecular orbitals. These groups of molecular orbitals are so closely placed together to form continuous regions of energies, known as the bands.
The energy difference between these bands is known as the band gap.
Conductor, Semiconductor,...
The energy difference between these bands is known as the band gap.
Conductor, Semiconductor,...
17.3K
02:31Scientific Laws and Theories
89.1K
Scientific Laws
89.1K
00:56Attribution Theory
13.8K
Behavior is a product of both the situation (e.g., cultural influences, social roles, and the presence of bystanders) and of the person (e.g., personality characteristics). Subfields of psychology tend to focus on one influence or behavior over others. Situationism is the view that our behavior and actions are determined by our immediate environment and surroundings. In contrast, dispositionism holds that our behavior is determined by internal factors (Heider, 1958).
13.8K