Peripheral Resistance Baroreflex During Incremental Bicycle Ergometer Exercise: Characterization and Correlation With
Alberto Porta1,2, Vlasta Bari2, Beatrice De Maria3
1Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Frontiers in Physiology
|June 21, 2018
Summary
This study characterizes the baroreflex controlling peripheral resistances (prBR) and cardiac baroreflex (cBR) during exercise. Findings suggest prBR offers complementary information to cBR for patient risk stratification.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Regulation
- Exercise Physiology
Background:
- The baroreflex (BR) is crucial for maintaining cardiovascular homeostasis.
- Existing methods primarily focus on the cardiac BR (cBR), leaving the peripheral resistance BR (prBR) less characterized.
- Understanding prBR during physiological challenges like exercise is essential.
Purpose of the Study:
- To characterize the prBR and cBR during incremental exercise.
- To assess the sensitivity, involvement, and effectiveness of both prBR and cBR under varying exercise intensities.
- To determine if prBR provides information complementary to cBR.
Main Methods:
- Utilized laser Doppler flowmetry for skin blood flow and plethysmography for arterial pressure.
- Estimated peripheral resistances (PR) beat-by-beat.
- Developed sequence analysis methods to quantify prBR sensitivity (BRSprBR), sequence percentage (SEQ%prBR), and effectiveness index (EIprBR), analogous to cBR markers.
- Subjects underwent incremental bicycle ergometer exercise.
Main Results:
- BRScBR decreased with exercise intensity, while BRSprBR declined only at the highest workload.
- SEQ%prBR significantly decreased with exercise, unlike SEQ%cBR which varied with intensity.
- EIprBR and EIcBR remained unaffected by exercise.
- Pooled data showed correlations between cBR and prBR sequence percentages and effectiveness indices, but not sensitivities.
- These correlations were not consistently detected under specific experimental conditions.
Conclusions:
- prBR exhibits distinct responses to exercise compared to cBR.
- prBR characterization provides unique insights potentially valuable for clinical applications.
- The findings suggest prBR assessment complements cBR, aiding in improved patient risk stratification.
Keywords:
autonomic nervous systemcardiovascular controlheart rate variabilitylaser Doppler skin blood flowperipheral resistancesrehabilitationsport medicinevasomotionMore Related Videos
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