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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

Published on: April 16, 2013

Development of B lymphocyte function in childhood

U Andersson

    Acta Paediatrica Scandinavica
    |July 1, 1985
    PubMed

    The capacity of blood lymphocytes of children aged from birth to six years to produce immunoglobulins was studied in vitro at the cell level using a direct B lymphocyte activator (Epstein-Barr virus) or a T lymphocyte dependent B lymphocyte activator (pokeweed mitogen). Umbilical cord blood lymphocytes secreted IgM at adult levels after Epstein-Barr virus stimulation, while the ability to synthesize IgG and IgA increased up to the ages of 1 and 2 years, respectively, but not beyond this period. IgG3 production preceded that of the other IgG subclasses. The T lymphocyte dependent IgM synthesis was low at birth, but approached adult levels at two years of age. T cell dependent IgG and IgA secretion, however, remained reduced even up to 6 years of age.

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