Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of B lymphocyte function in childhood.

U Andersson

    Acta Paediatrica Scandinavica
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Infant lymphocytes show distinct immunoglobulin production capabilities. While IgM is produced at adult levels early on, IgG and IgA production matures later, with T-cell dependent responses lagging in young children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sexual harassment among employees and students at a large Swedish university: who are exposed, to what, by whom and where - a cross-sectional prevalence study.

    BMC public health·2022
    Same author

    Comparison of bleeding risk scores in patients with atrial fibrillation: insights from the RE-LY trial.

    Journal of internal medicine·2017
    Same author

    The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.

    Journal of internal medicine·2017
    Same author

    The functions of HMGB1 depend on molecular localization and post-translational modifications.

    Journal of internal medicine·2014
    Same author

    D-dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation--observations from the ARISTOTLE trial.

    Journal of thrombosis and haemostasis : JTH·2014
    Same author

    HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.

    Journal of internal medicine·2013

    Area of Science:

    • Immunology
    • Pediatric immunology
    • Cellular immunology

    Background:

    • Immunoglobulin production by lymphocytes is crucial for immune defense.
    • Understanding the ontogeny of B cell function in early childhood is essential for assessing immune competence.
    • Early life immune responses differ significantly from adult patterns.

    Purpose of the Study:

    • To investigate the in vitro immunoglobulin production capacity of blood lymphocytes in children from birth to six years.
    • To differentiate the responses of B lymphocytes stimulated directly versus T-cell dependent pathways.
    • To characterize the developmental trajectory of specific immunoglobulin (IgM, IgG, IgA) synthesis in early childhood.

    Main Methods:

    • In vitro study of blood lymphocytes from children aged 0-6 years.

    Related Experiment Videos

  • Stimulation of B lymphocytes using Epstein-Barr virus (direct activator).
  • Stimulation of B lymphocytes using pokeweed mitogen (T-cell dependent activator).
  • Quantification of immunoglobulin secretion at the cellular level.

    • Main Results:

    • Umbilical cord blood lymphocytes produced IgM at adult levels upon Epstein-Barr virus stimulation.
    • IgG and IgA synthesis capacity increased with age, reaching a plateau by 1 and 2 years, respectively.
    • IgG3 subclass production was observed to precede other IgG subclasses.
    • T-cell dependent IgM synthesis was low at birth, reaching adult levels by 2 years.
    • T-cell dependent IgG and IgA secretion remained reduced up to 6 years of age.

    Conclusions:

    • Neonatal B cells exhibit functional maturity for direct IgM production.
    • The development of IgG and IgA synthesis is age-dependent, with distinct maturation timelines.
    • T-cell dependent B cell responses mature more slowly than T-cell independent responses in early childhood.
    • These findings highlight specific windows of immune vulnerability and maturation in infants and young children.