Related Experiment Video
Updated: Feb 8, 2026

A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix
Published on: October 7, 2013
Trapeziectomy with Interpositional Arthroplasty using Acellular Dermal Matrix: Description of Technique and Early
April C Cockcroft1, Alexey M Markelov2
1WesternU College of Osteopathic Medicine of the Pacific-Northwest, Lebanon, Ore.
Background:
Trapeziectomy with interpositional arthroplasty using Repriza acellular dermal matrix is a novel technique to treat primary and secondary carpometacarpal joint arthritis. Early studies with nonautograft interposition indicate promising post-trapeziectomy space maintenance with results similar to ligament reconstruction with tendon interposition, without the potential risks and increased operating time of harvesting a tendon autograft.
Methods:
Eleven patients in a retrospective cohort were followed for a minimum of 6 weeks (mean, 12). Subjective and objective data were collected to assess pain, subjective improvement of symptoms, radiographic measurements of first metacarpal subsidence, key pinch strength, grip strength, and range of motion.
Results:
Early outcomes in our cohort compare favorably to other treatment series. On average, patients received a significant pain reduction of 63%, with 36% of patients admitting to complete pain resolution. One hundred percentage of patients admitted to overall subjective improvement in symptoms. Ninety-one percentage of patients achieved postoperative opposition of the thumb and fifth digit. Comparison with preoperative x-rays showed mean thumb metacarpal subsidence of 27%. Zigzag deformity and extra-articular acellular dermal matrix migration, due to lack of patient compliance with splint, were observed complications. Only 8.3% subsidence was observed with an impressive 45% pain reduction, in a salvage patient after revision surgery for a NuGrip implant.
Conclusions:
In conclusion, this is a safe and effective primary or salvage technique for Eaton grades III and IV thumb carpometacarpal arthritis with a mean subsidence within the range observed with ligament reconstruction with or without tendon interposition. Long-term study with a larger sample size is needed to investigate this technique further.
Related Concept Videos
Pleural Disorders: Types and Brief Description
Eulerian and Lagrangian Flow Descriptions
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
Predicting Reaction Outcomes
The Extracellular Matrix
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...

