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Related Concept Videos

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

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Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
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Gastritis-I: Introduction and Types01:27

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
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Gastritis III: Clinical Manifestations and Management01:23

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
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Helicobacter pylori: Does Gastritis Prevent Colitis?

Isabelle C Arnold1, Anne Müller1

  • 1Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.

Inflammatory Intestinal Diseases
|June 21, 2018
PubMed
Summary

Helicobacter pylori infection may protect against inflammatory bowel disease (IBD). Research shows an inverse association, particularly in Crohn's disease, with potential therapeutic implications for IBD treatment.

Keywords:
Bacterial immunomodulationEpidemiological studiesHost/pathogen interactionMicrobiota and inflammatory bowel disease riskPathogenesis of gastritis and colitis

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Area of Science:

  • Gastroenterology and immunology
  • Microbiome research
  • Infectious diseases

Background:

  • Helicobacter pylori (H. pylori) is linked to gastric diseases but may also prevent allergies and chronic inflammation.
  • Chronic H. pylori infection causes gastritis and is a risk factor for ulcers and gastric cancer.
  • Emerging evidence suggests H. pylori may have a protective role against inflammatory bowel disease (IBD).

Purpose of the Study:

  • To review current evidence on the inverse association between H. pylori infection and IBD risk.
  • To explore experimental and human observational studies on this relationship.
  • To discuss the dual role of H. pylori in host health and disease.

Main Methods:

  • Analysis of epidemiological data from European, Asian, and American populations.
  • Review of experimental data from mouse models of IBD.
  • Examination of proposed mechanisms of H. pylori's immunomodulatory effects.

Main Results:

  • Epidemiological data consistently show an inverse association between H. pylori infection and IBD (Crohn's disease and ulcerative colitis).
  • This inverse association is stronger in Crohn's disease patients, children, and young adults.
  • Experimental studies confirm that H. pylori infection or its molecules reduce IBD symptoms in mouse models.

Conclusions:

  • H. pylori infection appears to have a protective effect against IBD development.
  • Mechanisms include tolerizing dendritic cells, producing protective cytokines, and promoting regulatory T-cells.
  • Findings have implications for H. pylori eradication decisions and potential IBD therapies.