Related Experiment Video
Updated: Feb 8, 2026
08:51
Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
20.2K
Application of pharmacogenetics in clinical practice: problems and solutions
Andrius Baskys1,2,3
1Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA. abaskys@gmail.com.
Journal of Neural Transmission (Vienna, Austria : 1996)
|June 21, 2018
Summary
Integrating pharmacogenomic data into clinical practice is challenging. Simple bioinformatics tools are needed for prescribers to quickly use genetic information for patient care decisions.
Area of Science:
- Bioinformatics
- Clinical Pharmacology
- Genetics
Background:
- Pharmacogenomic data holds potential for personalized medicine.
- Current clinical integration of pharmacogenomics faces significant hurdles.
Purpose of the Study:
- To highlight challenges in implementing pharmacogenomic data in routine healthcare.
- To advocate for the development of user-friendly bioinformatics solutions.
Main Methods:
- Literature review and analysis of current clinical integration barriers.
- Discussion of existing bioinformatics tool limitations.
Main Results:
- Significant difficulties exist in translating pharmacogenomic research into clinical practice.
- A gap identified between genetic data availability and its practical application by clinicians.
Conclusions:
- Development of intuitive bioinformatics tools is crucial for effective pharmacogenomic data utilization.
- Streamlined access to genetic data at the point of care can improve clinical decision-making and patient outcomes.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
1.5K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.5K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
762
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
762
01:16Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
1.4K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
1.4K
02:24Ideal Solutions
22.6K
According to Raoult’s law, the partial vapor pressure of a solvent in a solution is equal or identical to the vapor pressure of the pure solvent multiplied by its mole fraction in the solution. However, Raoult's Law is only valid for ideal solutions. For a solution to be ideal, the solvent-solute interaction must be just as strong as a solvent-solvent or solute-solute interaction. This suggests that both the solute and the solvent would use the same amount of energy to escape to the...
22.6K
02:12General Properties of Solutions
36.0K
Many common substances around us exist as a solution, such as ocean water, air, and gasoline. All solutions are mixtures of substances that are composed of varying amounts of two or more types of atoms or molecules. A mixture with a non-uniform composition is a heterogeneous mixture, whereas a mixture with a uniform composition is a homogeneous mixture. The components that make the homogeneous mixture are evenly spread out and thoroughly mixed.
36.0K