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A Free-breathing fMRI Method to Study Human Olfactory Function
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Olfactory Function in SCA10.

Mariana Moscovich1,2, Renato Puppi Munhoz3, Adriana Moro4

  • 1Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. marimoscovich@hotmail.com.

Cerebellum (London, England)
|June 21, 2018
PubMed
Summary

Spinocerebellar ataxia type 10 (SCA10) patients do not exhibit significant olfactory deficits, unlike those with Parkinson's disease. This study compared olfactory function in SCA10, SCA3, Parkinson's disease, and healthy individuals.

Keywords:
Cerebellar degenerationMovement disordersOlfactionSmellSpinocerebellar ataxia

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Area of Science:

  • Neurology
  • Neuroscience
  • Genetics

Background:

  • Spinocerebellar ataxias (SCAs) primarily affect the cerebellum but can involve other systems.
  • Olfactory deficits are known in some ataxias, particularly SCA3, but remain unstudied in SCA10.

Purpose of the Study:

  • To investigate and compare olfactory function in patients with Spinocerebellar Ataxia type 10 (SCA10) against SCA3, Parkinson's disease (PD), and healthy controls.

Main Methods:

  • Olfactory identification was assessed using the Sniffin' Sticks (SS16) test in 30 SCA10 patients, 30 SCA3 patients, 30 PD patients, and 44 healthy controls.
  • Statistical analyses were performed adjusting for age, gender, and smoking history.

Main Results:

  • SCA10 patients showed no significant difference in SS16 scores compared to SCA3 patients and healthy controls.
  • SCA10 patients had significantly higher SS16 scores than PD patients.
  • No correlation was found between olfactory scores and disease duration or repeat expansions in SCA10 or SCA3.

Conclusions:

  • This study indicates that SCA10 does not present with significant olfactory deficits.
  • Olfactory function appears preserved in SCA10, distinguishing it from conditions like Parkinson's disease.