Related Experiment Video

Updated: Feb 8, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

MicroRNAs in regulation of triple-negative breast cancer progression

Dominika Piasecka1, Marcin Braun1,2, Radzislaw Kordek1

  • 1Department of Pathology, Medical University of Lodz, Lodz, Poland.

Journal of Cancer Research and Clinical Oncology
|June 21, 2018
PubMed
Abstract

Insights

Specific microRNAs are dysregulated in triple-negative breast carcinoma (TNBC), impacting invasion and stemness. Understanding these microRNA profiles aids in TNBC prognostication and therapy development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA (miRNA) dysregulation is implicated in various human cancers.
  • Triple-negative breast carcinoma (TNBC) lacks predictive markers and therapeutic targets.
  • Specific miRNA clusters may hold clinical utility in TNBC management.

Purpose of the Study:

  • To comprehensively review microRNAs in TNBC.
  • To analyze miRNA targets and their roles in invasion, epithelial-to-mesenchymal transition (EMT), and cancer stem cell (CSC) properties.
  • To assess the significance of miRNAs for TNBC therapy.

Main Methods:

  • Systematic literature search of PubMed and Medline databases.
  • Analysis of 121 selected articles on microRNAs in TNBC.
  • Identification of significantly up- or down-regulated miRNAs associated with EMT/CSC and invasion.

Main Results:

  • Upregulated miRNAs in TNBC include miR-10b, miR-21, miR-29, miR-9, miR-221/222, and miR-373.
  • Downregulated miRNAs in TNBC include miR-145, miR-199a-5p, miR-200 family, miR-203, and miR-205.
  • Dysregulation of specific miRNAs (e.g., miR-10b, miR-21, miR-200 family) shows prognostic value in TNBC patients.

Conclusions:

  • Specific microRNA clusters play a crucial role in TNBC biology.
  • Understanding these miRNA roles can improve TNBC prognostication.
  • MicroRNAs offer potential for developing novel TNBC therapies.
Keywords:
CSCEMTInvasionMicroRNATriple-negative breast carcinoma

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.8K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.5K
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K