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Published on: September 29, 2018
Nasopharyngeal Papillary Adenocarcinoma as a Second Head and Neck Malignancy
Aanchal Kakkar1, Pirabu Sakthivel2, Swati Mahajan3
1Departments of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India. aanchalkakkar@gmail.com.
Abstract:
Nasopharyngeal adenocarcinomas are rare tumours, and include neoplasms arising from the nasopharyngeal surface epithelium as well as those of minor salivary gland origin, each of which is distinct from the other. The former encompasses nasopharyngeal papillary adenocarcinoma (NPAC), also known as low grade NPAC and thyroid-like NPAC, an extremely unusual malignancy bearing histomorphological similarity to papillary thyroid carcinoma, and displaying indolent clinical behaviour. We report the case of a 41-year-old lady who developed NPAC as a second malignancy five-and-a-half years after being diagnosed and treated for a diffuse astrocytoma in the frontal lobe. In addition, we discuss the differential diagnosis, as well as raise certain pathogenetic considerations with regard to this unique neoplasm.
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