Related Experiment Video
Updated: Feb 8, 2026

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
Change in VO2max and time trial performance in response to high-intensity interval training prescribed using
Todd A Astorino1, Jamie deRevere2,3, Theodore Anderson2,4
1Department of Kinesiology, California State University, San Marcos, 333. S. Twin Oaks Valley Road, UNIV 320, San Marcos, CA, 92096-0001, USA. astorino@csusm.edu.
High-intensity interval training (HIIT) improved VO2max and cycling performance, but individual responses varied. Prescribing HIIT using ventilatory threshold (VT) may require adjustments in volume to benefit all athletes.
Area of Science:
- Exercise Physiology
- Sports Science
- Cardiovascular Health
Background:
- High-intensity interval training (HIIT) is known to enhance maximal oxygen uptake (VO2max) and oxidative capacity.
- However, a significant portion of individuals (20-40%) exhibit minimal or no improvement in VO2max in response to standardized HIIT protocols.
- This variability suggests that a homogeneous approach to HIIT prescription may not be optimal for all individuals.
Purpose of the Study:
- To investigate the effects of prescribing HIIT based on ventilatory threshold (VT) on VO2max and cycling performance.
- To assess individual variability in response to VT-prescribed HIIT.
Main Methods:
- Fourteen active adults completed nine HIIT sessions on a cycle ergometer, with training intensity set at 130% of their VT.
- Each session involved 8-10 intervals of 1-minute duration, separated by 75-second recovery periods.
- VO2max and 5-mile cycling time trial performance were assessed at baseline and post-intervention. A control group of 14 participants did not undergo training.
Main Results:
- HIIT significantly increased VO2max by 6%, cycling performance by 2.5%, and absolute VT by 9 W compared to the control group.
- Despite these group-level improvements, only 57% of participants showed meaningful gains in VO2max and cycling performance.
- Two participants demonstrated no improvement in either VO2max or cycling performance.
Conclusions:
- Prescribing HIIT using VT can lead to significant physiological and performance adaptations.
- A substantial inter-individual variability in response to VT-prescribed HIIT persists.
- Increasing the volume of HIIT may be necessary to elicit optimal training responses in all individuals.
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