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p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function
Zhongjian Xie1,2,3, Yuanyuan Tang1,3, Mao-Qiang Man4
1Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Journal of Cellular Physiology
|June 21, 2018
Summary
p120-catenin (p120) is crucial for skin barrier function. Conditional knockout of p120 in epidermis increases proliferation, impairs differentiation, and compromises permeability barrier, highlighting its regulatory role.
Area of Science:
- Dermatology
- Cell Biology
- Molecular Biology
Background:
- p120-catenin (p120) is a key regulator of E-cadherin, essential for cell adhesion.
- The specific role of p120 in epidermal homeostasis and barrier function remains largely undefined.
- Previous global knockout studies indicated effects on proliferation but not differentiation or permeability.
Purpose of the Study:
- To investigate the precise function of p120 in the epidermis.
- To determine the impact of p120 deficiency on epidermal proliferation, differentiation, and barrier function.
Main Methods:
- Generation of a conditional knockout mouse model with epidermal-specific deletion of p120.
- Assessment of epidermal proliferation, differentiation markers, and skin permeability.
Main Results:
- Conditional knockout of p120 in the epidermis led to significantly increased epidermal proliferation.
- Epidermal differentiation was markedly decreased in p120-deficient epidermis.
- Skin permeability barrier function was compromised following conditional p120 knockout.
Conclusions:
- p120-catenin is essential for suppressing epidermal proliferation.
- p120 plays a critical role in promoting epidermal differentiation.
- p120 is required for maintaining the integrity and function of the epidermal permeability barrier.
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