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Updated: Feb 8, 2026
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A 1.5 Hour Procedure for Identification of Enterococcus Species Directly from Blood Cultures
Published on: February 10, 2011
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The emergence of multi-resistant Enterococcus faecalis clonal complex, CC4, causing nosocomial infections
Dongfa Dai1, Huizhu Wang2, Xinmin Xu2
11Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, PR China.
Journal of Medical Microbiology
|June 21, 2018
Summary
Emerging high-risk Enterococcus faecalis strains, particularly CC4, show increasing multi-resistance in Chinese hospitals. Enhanced surveillance is crucial for preventing and treating these nosocomial infections effectively.
Area of Science:
- Microbiology
- Epidemiology
- Infectious Diseases
Background:
- Enterococcus faecalis is a common gut bacterium.
- Certain lineages cause significant extra-intestinal and nosocomial infections.
- High-level virulence and antimicrobial resistance are key concerns in healthcare settings.
Purpose of the Study:
- To investigate the epidemiological characteristics of E. faecalis causing nosocomial infections.
- To determine the antimicrobial susceptibility profiles of these isolates.
- To identify prevalent and emerging E. faecalis subtypes in a Chinese hospital.
Main Methods:
- Collected 77 E. faecalis isolates from extra-intestinal infections (2011-2014).
- Utilized multilocus sequence typing and MLVA for population genetics.
- Assessed antimicrobial susceptibility using the Kirby-Bauer disk diffusion method against 11 agents.
Main Results:
- High resistance rates observed for tetracycline (86.5%), erythromycin (78.4%), and rifampin (62.2%).
- Major clonal complexes (CCs) identified: CC4, CC16, and CC21.
- CC16 prevalence decreased, while CC4 and CC21 increased, with CC4 exhibiting higher resistance.
Conclusions:
- Identified prevalent E. faecalis subtypes and resistance patterns in nosocomial infections.
- CC4 emerged as a potential high-risk, multi-drug resistant cluster.
- Urgent need for enhanced surveillance to guide prevention and treatment strategies.
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