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Updated: Aug 8, 2026
07:55
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Myelogenous leukemia and bilateral exudative retinal detachment
Annals of Ophthalmology
|December 1, 1979
Abstract:
A 47-year-old woman with a diagnosis of myelogenous leukemia presented with poor vision secondary to bilateral exudative retinal detachments. Chemotherapy improved her leukemia status and her vision improved but her retinal pigment epithelium became diffusely mottled and irregular, presumably because of a toxic effect from the exudative subretinal fluid. Clinical and fluorescein findings are presented.
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The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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