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Updated: Feb 8, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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[Progress of marine anticancer agents targeting cellular proapoptotic molecules]

Cong Li, Huan-li Xu, Ming Liu

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |June 21, 2018
    PubMed

    Insights

    Marine natural products show promise as anti-cancer drugs by activating apoptosis, programmed cell death, in tumor cells. This review explores these compounds and their potential in cancer chemotherapy.

    Area of Science:

    • Oncology
    • Marine Biology
    • Pharmacology

    Background:

    • Apoptosis, or programmed cell death, is a natural process crucial for eliminating harmful cells and preventing cancer.
    • Activating apoptotic pathways is a key strategy for developing effective cancer chemotherapeutic agents.
    • Marine natural products are increasingly recognized as a valuable source for novel anti-cancer drug discovery.

    Purpose of the Study:

    • To review marine natural products that induce apoptosis in tumor cells.
    • To analyze the effects of these compounds on apoptotic signaling pathways.
    • To highlight challenges in developing anti-cancer drugs from marine natural products.

    Main Methods:

    • Literature review of marine compounds with anti-tumor activity.
    • Analysis of studies detailing the impact of marine compounds on apoptosis.
    • Summary of research on marine-derived anti-cancer agents and their mechanisms.

    Main Results:

    • Numerous marine compounds have demonstrated the ability to induce apoptosis in various cancer cell types.
    • Several marine-derived compounds exhibit significant anti-tumor activity.
    • The mechanisms of action often involve modulation of specific apoptotic signaling pathways.

    Conclusions:

    • Marine natural products represent a promising resource for the development of novel anti-cancer therapies.
    • Further research is needed to overcome challenges in drug development, including bioavailability and targeted delivery.
    • Understanding the effects on apoptotic pathways is critical for optimizing the therapeutic potential of these compounds.

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