Related Experiment Video
Updated: Feb 8, 2026

Isolation of Lymphocytes from Mouse Genital Tract Mucosa
Published on: September 3, 2012
Increased expression of p16 in both oral and genital lichen planus
K Danielsson1, J Olah, R Zohori-Zangeneh
1Department of Odontology, Umeå University, SE - 901 85 Umeå, Sweden, majid.ebrahimi@umu.se.
Background:
Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Since the discovery of p16 several studies have evaluated its expression in various forms of human cancers. The aim of this study was to evaluate and compare the expression of p16 in oral and genital LP and corresponding healthy mucosa.
Material And Methods:
A total of 76 cases of oral LP (OLP), 34 cases of genital LP (GLP), 12 cases of healthy oral and 9 cases of healthy genital mucosa were analysed by the use of immunohistochemistry.
Results:
Data showed p16 to be highly expressed in both oral and genital LP, higher than in oral (p=0.000), and genital controls (p=0.002).
Conclusions:
Results suggest that the over-expression of p16 seen in LP play a part in the histopathology of the disease.
More Related Videos
Related Concept Videos
External Female Genitals
Psychosexual Stages of Personality: Genital
Increasing Function
Oral Cavity
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Increased Body Temperature
Increased pulse rate
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...

