Immune Checkpoint Blockade across the Cancer Care Continuum
Beth A Helmink1, Pierre-Olivier Gaudreau2, Jennifer A Wargo3
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Immunity
|June 21, 2018
Summary
Immune checkpoint blockade therapies show significant promise in treating various cancer stages. These treatments are effective as single agents or in combination, offering new options for front-line cancer care.
Area of Science:
- Oncology
- Immunotherapy
Background:
- Immune checkpoint blockade (ICB) has revolutionized cancer treatment.
- Advances in ICB are expanding its application across the cancer care continuum.
Purpose of the Study:
- To highlight recent advances in immune checkpoint blockade therapy.
- To demonstrate the efficacy of ICB in early and late-stage cancers.
Main Methods:
- Review of four recent studies published in the New England Journal of Medicine.
- Analysis of ICB efficacy in monotherapy and combination regimens.
Main Results:
- ICB demonstrates efficacy in both early and late-stage disease.
- ICB can be used as a standalone therapy or in combination with other treatments.
- ICB can be administered in addition to or as a replacement for standard front-line therapy.
Conclusions:
- Immune checkpoint blockade represents a significant advancement in cancer treatment.
- ICB offers versatile therapeutic strategies across the cancer care continuum.
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