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Bat Astrovirus in Mozambique.

Flora Hoarau1, Gildas Le Minter1, Léa Joffrin1

  • 1Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, 2 rue Maxime Rivière (GIP CYROI), 97490 Sainte-Clotilde, La Réunion, France.

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Astroviruses (AstVs) circulate widely in bats in Mozambique, with 20.1% shedding the virus. This highlights the potential for astrovirus zoonotic transmission in the western Indian Ocean region.

Keywords:
MadagascarMammastrovirusMayotteMozambiqueTriaenops afer

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Area of Science:

  • Virology
  • Zoonotic Diseases
  • Bat Ecology

Background:

  • Astroviruses (AstVs) infect diverse mammalian and avian species, including humans.
  • Bats are known reservoirs for various viruses, necessitating investigation into AstV circulation within bat populations.

Purpose of the Study:

  • To investigate the circulation and diversity of astroviruses in bats from Mozambique and Mayotte.
  • To assess the potential for zoonotic transmission of astroviruses from bats.

Main Methods:

  • Collection of biological samples from 338 bats in Mozambique and Mayotte.
  • Detection of the AstV RNA-dependent RNA-polymerase gene using a pan-AstV semi-nested polymerase chain reaction assay.

Main Results:

  • Astroviruses were detected in 20.1% of bats sampled in Mozambique, with significant interspecific variation.
  • No AstVs were detected in bats from Mayotte.
  • Phylogenetic analysis revealed diverse AstV lineages, with some suggesting host-virus associations and links to viruses found in Malagasy bats.

Conclusions:

  • Active circulation of diverse astroviruses in bats along the southeastern African coast and western Indian Ocean islands is supported.
  • Further assessment of astrovirus zoonotic transmission risk to human populations is warranted.