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In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
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Pharmacokinetics: Drug–Drug Interactions01:25

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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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FDA Approved Drugs: Changes to Approved Drugs01:26

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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Thermal Measurement Techniques in Analytical Microfluidic Devices
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Microfluidic Devices for Drug Assays.

Clément Regnault1, Dharmendra S Dheeman2, Axel Hochstetter3

  • 1Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. c.regnault.1@research.gla.ac.uk.

High-Throughput
|June 22, 2018
PubMed
Summary
This summary is machine-generated.

This review overviews microfluidic-based high-throughput drug assays, comparing various methods like droplet and continuous flow systems. It highlights promising techniques that could advance future drug screening technologies.

Keywords:
continuous flow microfluidicsdroplet-microfluidicsdrug assaysdrug discoveryhigh-throughputmicrofluidicsreviewwell plates

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Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Analytical Chemistry

Background:

  • High-throughput drug screening is crucial for identifying novel therapeutics.
  • Microfluidic technologies offer advantages in assay miniaturization and efficiency.
  • Diverse microfluidic approaches are being explored for drug discovery.

Purpose of the Study:

  • To provide a comprehensive overview of current microfluidic-based high-throughput drug assay methodologies.
  • To compare and contrast different microfluidic techniques used in drug screening.
  • To identify emerging and promising microfluidic approaches for future drug discovery.

Main Methods:

  • Systematic review of over 100 recent publications in microfluidic drug assays.
  • Categorization of reviewed studies based on their microfluidic approach (e.g., droplet, continuous flow, gradient-based).
  • Comparative analysis of the strengths and limitations of various microfluidic platforms.

Main Results:

  • Microfluidic drug assays encompass diverse strategies including microtiter plates, droplet microfluidics, and continuous flow systems.
  • Gradient-based microfluidic assays show particular promise for complex drug response studies.
  • The field is rapidly evolving with innovative approaches continually emerging.

Conclusions:

  • Microfluidics provides a powerful and versatile platform for high-throughput drug screening.
  • Continued development in microfluidic technologies is expected to significantly impact drug discovery pipelines.
  • Interdisciplinary collaboration is key to advancing this innovative research field.