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The prostasome: its secretion and function in man.

G Ronquist, I Brody

    Biochimica Et Biophysica Acta
    |September 9, 1985
    PubMed
    Summary
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    The human prostate gland secretes prostasomes, which are organelles released via exocytosis or diacytosis. These prostasomes contain ATPase and protein kinase activity, potentially aiding sperm motility.

    Area of Science:

    • Urology
    • Cell Biology
    • Biochemistry

    Background:

    • The human prostate gland secretes prostasomes, which are intact organelles.
    • Prostasomes are stored within membrane-bound vesicles in the prostate's acinar epithelial cells.

    Purpose of the Study:

    • To investigate the ultrastructural mechanisms of prostasome secretion from human prostate epithelial cells.
    • To identify biochemical activities associated with prostasome membranes.

    Main Methods:

    • Ultrastructural analysis of human prostate acinar epithelial cells.
    • Biochemical assays to detect ATPase and protein kinase activity in prostasome membranes.

    Main Results:

    • Prostasomes are released into the glandular lumen through exocytosis or diacytosis, occurring with similar frequency.

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  • Prostasome membranes possess a Mg2+ and Ca2+-dependent ATPase system and protein kinase activity.
  • Phosphorylation by protein kinase activity increases prostasome membrane thickness.

    • Conclusions:

    • Prostasome secretion involves distinct cellular mechanisms (exocytosis and diacytosis).
    • The identified ATPase and kinase activities suggest roles in ion transport and membrane regulation.
    • The precise physiological function of prostasomes remains unknown but may relate to sperm motility.