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Updated: Feb 8, 2026

Preparation and Applications of Organotypic Thymic Slice Cultures
Published on: August 6, 2016
Thymic tolerance as a key brake on autoimmunity
Mickie Cheng1, Mark S Anderson2
1Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Abstract:
Although the thymus has long been recognized as a key organ for T cell selection, the intricate details linking these selection events to human autoimmunity have been challenging to decipher. Over the last two decades, there has been rapid progress in understanding the role of thymic tolerance mechanisms in autoimmunity through genetics. Here we review some of the recent progress in understanding key thymic tolerance processes that are critical for preventing autoimmune disease.
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