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Related Experiment Video

Updated: Feb 8, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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TRPM8 and prostate: a cold case?

Lucile Noyer1,2, Guillaume P Grolez1,2, Natalia Prevarskaya1,2

  • 1Inserm, U1003, Laboratory of Cell Physiology, University Lille Nord de France, 59655 Cedex, Villeneuve d'Ascq, France.

Pflugers Archiv : European Journal of Physiology
|June 22, 2018
PubMed
Summary

Transient receptor potential, melastatin member 8 (TRPM8) is more than a cold receptor. This review explores TRPM8's complex role in prostate cancer development, highlighting its potential for future clinical applications.

Keywords:
CalciumCancerMigrationProstateTRPM8

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Area of Science:

  • Oncology
  • Neuroscience
  • Molecular Biology

Background:

  • Transient receptor potential, melastatin member 8 (TRPM8) was initially cloned from prostate tissue.
  • TRPM8 is recognized as the primary cold and menthol receptor in the peripheral nervous system.
  • Its role in cancer, particularly prostate carcinogenesis, has been historically underestimated.

Purpose of the Study:

  • To review the current understanding of TRPM8's multifaceted roles in prostate carcinogenesis.
  • To emphasize the significance of TRPM8 research in oncology.
  • To highlight potential short-term clinical applications of TRPM8 research.

Main Methods:

  • Literature review of studies on TRPM8 expression and function.
  • Analysis of TRPM8's regulation by physiological factors like PSA and androgens.
  • Synthesis of evidence linking TRPM8 to prostate cancer progression.

Main Results:

  • TRPM8 is highly expressed in the prostate, with altered expression during cancer progression.
  • TRPM8 can be activated by non-cold stimuli through physiological factors (e.g., PSA, androgens).
  • Evidence suggests TRPM8 plays a significant, non-thermosensory role in prostate carcinogenesis.

Conclusions:

  • TRPM8's involvement in prostate carcinogenesis warrants further in-depth investigation.
  • Understanding TRPM8's non-cold sensing functions is crucial for cancer research.
  • TRPM8 represents a promising target for future clinical applications in prostate cancer therapy.