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Antibodies and natural immunity.

A H Greenberg

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1985
    PubMed
    Summary

    Natural antibodies, crucial for T-independent resistance, are produced by B cell priming from microbes. This natural antibody response enhances host survival against tumors and pathogens.

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    Area of Science:

    • Immunology
    • Microbiology
    • Oncology

    Background:

    • Natural antibodies are implicated in host defense against pathogens and tumors.
    • Their role in T-independent immune responses is a subject of ongoing research.

    Purpose of the Study:

    • To propose a mechanism for natural antibody production.
    • To highlight the survival advantage conferred by natural antibodies.

    Main Methods:

    • This article presents a theoretical argument and review of existing literature.
    • It synthesizes evidence on B cell repertoire priming and antibody function.

    Main Results:

    • Ubiquitous microorganisms and autoantigens "prime" the B cell repertoire.
    • This priming leads to the production of natural antibodies.

    Conclusions:

    • Natural antibody production, driven by microbial and autoantigen priming, is a key component of innate immunity.
    • These antibodies provide a survival advantage by contributing to natural resistance against disease.

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