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Classification and diagnosis of aggressive periodontitis
Daniel H Fine1, Amey G Patil1, Bruno G Loos2
1Department of Oral Biology, Rutgers School of Dental Medicine, Rutgers University - Newark, NJ, USA.
Journal of Clinical Periodontology
|June 22, 2018
Summary
Classifying aggressive periodontitis (AgP) has been challenging due to broad definitions and inconsistent research. New diagnostic criteria and technologies are needed to identify reliable genetic, host, and microbial risk markers.
Area of Science:
- Periodontology
- Genetics
- Microbiology
Background:
- The classification of aggressive periodontitis (AgP) has evolved since its initial description.
- Existing definitions and diagnostic criteria for AgP require re-evaluation.
Purpose of the Study:
- To review the existing literature on aggressive periodontitis.
- To revisit and refine the definitions and diagnostic criteria for AgP.
Main Methods:
- Extensive literature search across major scientific databases (PubMed, Medline, Cochrane, Scopus, Web of Science).
- Inclusion criteria focused on specific study designs, subject numbers, and data points.
- Data categorized for epidemiological, microbial, host, and genetic analyses of AgP.
Main Results:
- Epidemiologic studies highlighted ethnic and societal influences on AgP.
- Microbial DNA analysis showed some consistency but considerable variability.
- Host factor analysis yielded inconsistent results, and many genetic studies lacked sufficient power or scope.
Conclusions:
- Conflicting data in AgP research stems from broad classification, lack of longitudinal and topographic studies.
- Technological advancements and refined definitions are crucial for unbiased analysis of risk factors.
- Improved diagnostic capabilities for AgP are anticipated through identification of robust genetic, host, and microbial risk markers.
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