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Efficacy of Delayed versus Immediate Cord Clamping in Late Preterm Newborns following Normal Labor: A Randomized

Rasita Salae, Chamnan Tanprasertkul, Charintip Somprasit

    Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
    |June 22, 2018
    PubMed

    Insights

    Delayed cord clamping (DCC) in late preterm infants significantly increased hematocrit levels at 48 hours without serious complications. This practice may help prevent anemia in these vulnerable newborns.

    Area of Science:

    • Neonatal Medicine
    • Perinatal Research
    • Pediatric Hematology

    Background:

    • Premature neonates, particularly late preterm infants, are at risk for anemia due to low iron stores.
    • Delayed cord clamping (DCC) shows benefits in very low birth weight infants, but data for late preterm infants is limited.

    Purpose of the Study:

    • To evaluate the impact of DCC versus immediate cord clamping (ICC) on hematocrit levels in late preterm neonates.
    • To assess neonatal and maternal complications associated with DCC in this population.

    Main Methods:

    • A randomized controlled trial involving 100 pregnant women with preterm labor (34-36 weeks gestation).
    • Infants were assigned to either ICC or DCC (umbilical cord clamping at 120 seconds after birth).
    • Hematocrit and microbilirubin levels were measured at 48 hours postpartum; complications were recorded.

    Main Results:

    • Eighty-six neonates were analyzed; no significant baseline differences between groups.
    • The DCC group showed significantly higher hematocrit levels (55.4%) compared to the ICC group (47.6%) (p=0.02).
    • Microbilirubin levels were also higher in the DCC group (9.4 mg%) vs ICC (8.6 mg%) (p=0.04), with no differences in phototherapy or hospitalization duration.

    Conclusions:

    • Delayed cord clamping is effective in increasing hematocrit levels in late preterm neonates.
    • The procedure appears safe, with no serious adverse maternal or fetal complications observed.
    • Further research is warranted to fully understand the benefits of DCC in this specific infant population.
    Abstract

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