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Updated: Feb 8, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
Published on: August 30, 2017
Breaking the Nd3+-sensitized upconversion nanoparticles myth about the need of onion-layered structures
Nestor Estebanez1, Juan Ferrera-González, Laura Francés-Soriano
1Instituto de Ciencia Molecular (ICMol), University of Valencia, Catedrático José Beltrán 2, 46980, Paterna, Valencia, Spain. maria.gonzalez@uv.es julia.perez@uv.es.
Abstract:
Up to now, most strategies to build efficient 800 nm-light responsive upconversion nanoparticles (UCNPs) have included onion-layered structures, in which Nd3+ is confined within the inorganic crystal structure of at least one layer. We report here an easy room-temperature modular preparation of core-shell UCNPs consisting of NaYF4:Yb,Er(Tm)/NaYF4 (UCCS) with Nd3+ anchored at the organic capping by using cucurbituril[7] (CB[7]) as an adhesive. Strikingly, excitation at 800 nm effectively triggers the upconversion emission of UCCS@CB[7]@Nd nanohybrids.
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