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Related Experiment Videos

A response-specific conditioned aversion to rewarding hypothalamic stimulation in rats.

A J Greenshaw, Z A Aleksanyan, S N Kundu

    Brain Research
    |July 22, 1985
    PubMed
    Summary

    Rats learned that licking or nose-poking triggered brain stimulation. Pairing licking with illness (LiCl) reduced licking, but not nose-poking, suggesting sensory brain stimulation depends on behavior.

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    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Learning and Memory

    Background:

    • Rats self-stimulate via hypothalamic electrodes using distinct behaviors like licking or nose-poking.
    • Understanding how sensory properties of brain stimulation are perceived and learned is crucial.

    Purpose of the Study:

    • To investigate if the sensory experience of brain stimulation is modulated by the behavioral context.
    • To determine if learned associations between a specific behavior and illness affect the reward value of brain stimulation.

    Main Methods:

    • Rats were trained to self-stimulate using hypothalamic electrodes via nose-poking or licking.
    • Behavior-Lithium Chloride (LiCl) pairings were used to induce taste aversion.
    • Cross-over trials assessed the effect of learned illness associations on different self-stimulation behaviors.

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    Main Results:

    • Pairing licking with LiCl significantly reduced licking-maintained self-stimulation.
    • This attenuation was specific to the licking behavior; nose-poking remained unaffected.
    • Pairing nose-poking with LiCl did not affect either licking or nose-poking self-stimulation.

    Conclusions:

    • The sensory consequences of hypothalamic stimulation are context-dependent.
    • Learned associations between behavior and aversive outcomes selectively impact the motivated behavior, not the stimulation itself.
    • Behavioral output influences the perceived salience of brain stimulation reward.