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Related Experiment Videos

Opioids and consummatory behavior.

A S Levine, J E Morley, B A Gosnell

    Brain Research Bulletin
    |June 1, 1985
    PubMed
    Summary

    Opioids influence feeding behaviors, with kappa opioid receptors playing a key role. While opioid antagonists acutely reduce food intake, chronic use does not effectively decrease body weight.

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    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Endocrinology

    Background:

    • Opiates are known to influence ingestive behaviors, generally enhancing feeding.
    • Opioid antagonists typically decrease feeding behaviors.

    Purpose of the Study:

    • To review animal species' responsiveness to opiates regarding ingestive behaviors.
    • To explore opioid receptors, sites of action, glucose's role, and endocrine effects in opioid-induced feeding.

    Main Methods:

    • Literature review of studies on opioid modulation of feeding behaviors.
    • Analysis of evidence regarding specific opioid receptors and their involvement.

    Main Results:

    • Multiple opioid receptors are involved in modulating feeding.
    • The dynorphin/alpha-neo-endorphin kappa opioid receptor plays a significant role.
    • Opioid effects on feeding are primarily central, with potential peripheral contributions.

    Conclusions:

    • Opioid antagonists acutely block food intake but are ineffective for chronic weight management.
    • Chronic opiate administration can decrease body weight, while beta-endorphin autosensitization increases it.

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