Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

6.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.3K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased PKG transcription mediated by PI3K/Akt/FoxO1 pathway is involved in the development of nitroglycerin tolerance.

Biochemical and biophysical research communications·2018
Same author

Rhynchophylline Ameliorates Endothelial Dysfunction via Src-PI3K/Akt-eNOS Cascade in the Cultured Intrarenal Arteries of Spontaneous Hypertensive Rats.

Frontiers in physiology·2017
Same author

[Recent progress in the development of atherosclerosis: role of heat shock protein].

Sheng li ke xue jin zhan [Progress in physiology]·2014
Same author

Inhibitory effect of rhynchophylline on contraction of cerebral arterioles to endothelin 1: role of rho kinase.

Journal of ethnopharmacology·2014
Same author

[Redox modification of protein thiols in the regulation of cardiovascular functions].

Sheng li ke xue jin zhan [Progress in physiology]·2012
Same author

[Regulation of soluble guanylyl cyclase and its role in the treatment of cardiovascular diseases].

Sheng li ke xue jin zhan [Progress in physiology]·2012
Same journal

[Mechanical regulation mechanism on vascular remodeling induced by hypertension].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Progress on research methods of transcription factors].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Regulatory effect of miR-21 on peripheral nerve injury and regulation function].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[The protective effects and mechanisms of PPARγ in ischemia-reperfusion injury of tissues].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[The Regulation Effects of Carbon Monoxide in Cardiovascular Systems].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Research Progress in the Neurobiological Effects of Hydrogen Sulfide].

Sheng li ke xue jin zhan [Progress in physiology]·2018
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method
08:25

Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method

Published on: December 25, 2016

23.1K

[Nitric Oxide Signaling Pathway and Vascular Activity].

Yuan-Sheng Gao

    Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
    |June 22, 2018
    PubMed
    Summary
    This summary is machine-generated.

    The nitric oxide-cyclic guanosine 3

    More Related Videos

    Analytical Techniques for Assaying Nitric Oxide Bioactivity
    11:28

    Analytical Techniques for Assaying Nitric Oxide Bioactivity

    Published on: June 18, 2012

    18.5K
    Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
    08:32

    Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

    Published on: March 16, 2017

    13.3K

    Related Experiment Videos

    Last Updated: Feb 8, 2026

    Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method
    08:25

    Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method

    Published on: December 25, 2016

    23.1K
    Analytical Techniques for Assaying Nitric Oxide Bioactivity
    11:28

    Analytical Techniques for Assaying Nitric Oxide Bioactivity

    Published on: June 18, 2012

    18.5K
    Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
    08:32

    Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

    Published on: March 16, 2017

    13.3K

    Area of Science:

    • Physiology
    • Biochemistry
    • Molecular Biology

    Background:

    • The nitric oxide-cyclic guanosine 3',5'-monophosphate (cGMP)-cGMP dependent protein kinase signaling pathway is crucial for vascular function.
    • Recent advancements have shed light on the molecular mechanisms governing this pathway.

    Purpose of the Study:

    • To summarize recent progress in understanding the nitric oxide (NO)/cGMP signaling pathway.
    • To highlight the physiological significance of redox-dependent dimerization of signaling molecules.
    • To discuss the emerging role of cyclic inosine 3',5'-monophosphate in vasoconstriction.

    Main Methods:

    • Literature review of recent research.
    • Analysis of signaling molecule interactions.
    • Examination of physiological roles in vascular regulation.

    Main Results:

    • Redox-dependent dimerization of signaling molecules plays a significant physiological role.
    • Soluble guanylyl cyclase-derived cyclic inosine 3',5'-monophosphate acts as a novel vasoconstrictor messenger.

    Conclusions:

    • The NO/cGMP pathway is a key regulator of vascular function.
    • Understanding redox-dependent mechanisms and novel messengers like cyclic inosine 3',5'-monophosphate advances vascular biology.