The type IV secretion system in Helicobacter pylori.
Xiao-Yan Yuan1, Ying Wang1, Ming-Yi Wang1
1Department of Central Lab, Weihai Municipal Hospital Affiliated to Dalian Medical University, Weihai, Shandong, 264200, PR China.
Future Microbiology
|June 22, 2018
Summary
Helicobacter pylori uses four type IV secretion systems (T4SS) to cause gastroduodenal diseases. This review details these T4SS, including the cag pathogenicity island, and their roles in H. pylori pathogenesis.
Area of Science:
- Microbiology
- Pathogenesis
- Molecular Biology
Background:
- Helicobacter pylori (H. pylori) is a key factor in developing gastritis, peptic ulcers, MALT lymphoma, and gastric cancer.
- Bacterial virulence factors, particularly the cag pathogenicity island (a type IV secretion system or T4SS), significantly influence host inflammatory responses.
Purpose of the Study:
- To systematically review the four type IV secretion systems (T4SS) encoded by H. pylori.
- To explore the roles of these T4SS in the pathogenesis of gastroduodenal diseases.
Main Methods:
- Systematic literature review of H. pylori T4SS.
- Analysis of the function and pathogenic contribution of cag-T4SS, comB, tfs3, and tfs4.
Main Results:
- H. pylori possesses at least four distinct T4SS: cag-T4SS, comB, tfs3, and tfs4.
- The cag-T4SS is crucial for delivering the CagA effector into host cells, modulating host responses.
Conclusions:
- Understanding the diverse T4SS of H. pylori is vital for elucidating its pathogenic mechanisms.
- This review provides insights into how H. pylori T4SS contribute to gastroduodenal diseases, potentially informing future therapeutic strategies.
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