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Updated: Feb 8, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
The relationship between gene polymorphism of MTRR A66G and lower extremity deep venous thrombosis
Jiasheng Xu1,2, Weimin Zhou1
1a Vascular Surgery Center , The Second Affiliated Hospital of Nanchang University , Nanchang , People's Republic of China.
Objective:
To investigate the relationship between gene polymorphism of MTRR A66G and lower extremity deep venous thrombosis (DVT).
Methods:
Two hundred and two patients with DVT as experimental group and 240 normal adults (control group) were enrolled in this study and white blood cells were collected, respectively. Polymorphism of the 66 loci in MTRR gene was detected by polymerase chain reaction-sequence-specific primers (PCR-SSP) in two groups. The frequency of genotype and allele distribution of each group was compared.
Results:
The frequency of AA, AG and GG genotypes in 66 sites of MTRR gene were 26.76%, 4 3.66% and 29.58% in DVT group and 43.57%, 44.28% and 12.14% in control group, respectively. There was no significant difference in the distribution frequency between two groups (χ = 3.2, P > .5).
Conclusions:
The gene polymorphism of MTRR A66G may not be an independent genetic risk factor in DVT in China.
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