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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Auditory Brainstem Pathology in Autism Spectrum Disorder: A Review.

Joseph P Pillion1,2, Dana Boatman-Reich3,4, Barry Gordon3,5

  • 1Department of Audiology, Kennedy Krieger Institute, Baltimore, Maryland.

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology
|June 22, 2018
PubMed
Summary
This summary is machine-generated.

Individuals with autism spectrum disorder (ASD) often show atypical sound responses due to auditory brainstem issues. Research indicates abnormalities in the auditory brainstem, particularly in younger children with ASD.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Audiology

Background:

  • Atypical sound responses are prevalent in autism spectrum disorder (ASD).
  • Evidence suggests underlying auditory brainstem pathology contributes to these responses.

Purpose of the Study:

  • To comprehensively review structural and functional evidence of auditory brainstem abnormalities in ASD.
  • To identify trends and patterns in auditory brainstem dysfunction within the ASD population.

Main Methods:

  • Systematic literature review of studies published between 1975 and 2016.
  • Analysis of structural imaging and electrophysiological data from multiple online databases.
  • Consideration of study quantity and quality indices.

Main Results:

  • Converging evidence supports auditory brainstem pathology in ASD, though specific structures and functions remain unclear.
  • Abnormalities are predominantly observed at higher auditory brainstem levels.
  • Brainstem abnormalities are more frequent in younger children with ASD, suggesting delayed neural maturation.

Conclusions:

  • Findings align with common auditory disorders in ASD, such as sound sensitivity and difficulty with sound localization.
  • Delayed maturation of brainstem neural pathways may explain observed auditory deficits.
  • Further research is needed to clarify specific anatomical and functional deficits.